The ability of IFN-gamma to inhibit replication of viruses correlated with the cells’ production of nitric oxide (NO). — The New Neander’s Medical

Short summary.

Interferons induce the expression of hundreds of antiviral genes. Inducible nitric oxide synthase (NOS) is stimulated by interferons and, thus, the production of large amounts of nitrogen oxyde (NO). A 1993 study by Karupiah et al. (1), that appears to be still factually correct, found that the activity of iNOS is both necessary and sufficient for a substantial antiviral effect of IFN-gamma in vitro.

In this article we share our notes and several curated citations from the paper by Karupiah et al., 1993 (1), and from several others.

Interferons induce the expression of hundreds of antiviral genes called interferon-stimulated genes.

Read et al., 2019 (2):

Interferons (IFNs) are immunostimulatory cytokines secreted from infected cells and nearby immune cells that induce the expression of hundreds of antiviral genes (called interferon-stimulated genes (ISGs)). They possess diverse roles including chemoattraction, immune cell activation, and direct antiviral activity.

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The ability of IFN-gamma to inhibit replication of viruses correlated with the cells’ production of nitric oxide (NO). — The New Neander’s Medical